Ma pyrogen, makamaka ponena za ma pyrogens a bakiteriya, ndi ma metabolites ena ang'onoang'ono, mitembo ya bakiteriya, ndi endotoxins. Ma pyrogens akalowa m'thupi la munthu, amatha kusokoneza chitetezo cha mthupi, zomwe zimayambitsa zizindikiro monga kuzizira, kuzizira, kutentha thupi, kutuluka thukuta, nseru, kusanza, komanso zotsatira zoopsa monga chikomokere, kugwa, ngakhale imfa. Mankhwala ophera tizilombo toyambitsa matenda monga formaldehyde ndi hydrogen peroxide sangathe kuchotseratu ma pyrogens, ndipo chifukwa cha kukana kwawo kutentha kwambiri, zida zonyowa zoziziritsira kutentha zimakhala zovuta kuwononga ntchito yawo yonse. Chifukwa chake, kutsekereza kutentha kowuma kwakhala njira yothandiza yochotsera ma pyrogens, yomwe imafunikira zida zapadera zoyezera - zida zowuma zowuma kutentha.
Msewu wowuma wowuma kutentha ndi chida chofunikira kwambiri chomwe chimagwira ntchito yofunika kwambiri m'mafakitale monga mankhwala ndi chakudya. Kupyolera mu njira zasayansi zochepetsera kutentha kowuma, kusalimba ndi mtundu wazinthu zitha kutsimikiziridwa, kuwonetsetsa kuti anthu ali ndi thanzi labwino komanso chitetezo, komanso kutenga gawo lofunikira pamzere wodzaza wosabala. Mfundo yake yogwirira ntchito ndikutenthetsa chidebecho ndi mpweya wouma wouma, kukwaniritsa kutsekereza kofulumira komanso kuchotsa pyrogen. Kutentha kotsekereza kumayikidwa pa 160 ℃ ~ 180 ℃ kuonetsetsa kuti mankhwalawa alibe tizilombo toyambitsa matenda, pamene kutentha kwa pyrogen kumakhala pakati pa 200 ℃ ~ 350 ℃. Zowonjezera za kope la 2010 la Chinese Pharmacopoeia limati "njira yotseketsa - njira yowuma yowuma kutentha" imafuna 250 ℃ × 45 mphindi zowuma zowuma kutentha zimatha kuchotsa zinthu za pyrogenic m'zotengera zosabala.
Zida zazitsulo zowuma zowonongeka zowonongeka nthawi zambiri zimakhala zitsulo zosapanga dzimbiri, zomwe zimafuna kuti mkati ndi kunja kwa bokosilo zikhale zopukutidwa, zosalala, zosalala, zopanda tokhala kapena zokopa. Chowotcha chomwe chimagwiritsidwa ntchito mu gawo la kutentha kwambiri chiyenera kupirira kutentha mpaka 400 ℃, ndipo zipangizozi zimafunikanso kuwunikira kutentha, kujambula, kusindikiza, alamu ndi ntchito zina, komanso kuyang'anira kuthamanga kwa mphepo ndi ntchito zowononga pa intaneti kuti zitheke. gawo lililonse.
Malingana ndi zofunikira za GMP, zitsulo zowuma zowuma kutentha zimayikidwa m'madera a A, ndipo ukhondo wa malo ogwirira ntchito uyeneranso kukwaniritsa zofunikira za Gulu la 100. zosefera mpweya, ndipo chifukwa cha malo awo apadera otentha kwambiri, zosefera zosagwira bwino kwambiri ziyenera kusankhidwa. Zosefera zosagwira kutentha kwambiri komanso zogwira bwino zimagwira ntchito yofunika kwambiri munjira zotsekera kutentha. Pambuyo pakuwotcha, mpweya wotentha kwambiri uyenera kudutsa fyulutayo kuti uwonetsetse kuti ukhondo ufika mpaka 100 ndikukwaniritsa zofunikira.
Kugwiritsa ntchito zosefera zotentha kwambiri komanso zowoneka bwino zimatha kuchepetsa kuipitsidwa kwa tizilombo tating'onoting'ono, tinthu tosiyanasiyana, ndi ma pyrogens. Pazofunikira pakupanga zinthu zosabala, ndikofunikira kusankha zosefera zotetezeka komanso zodalirika zolimbana ndi kutentha kwambiri. Munjira yovutayi, zinthu za FAF zolimbana ndi kutentha kwapamwamba zimapereka chitetezo chapamwamba pamakina owuma owuma, kuwonetsetsa kuti ntchitoyo ndi yotetezeka komanso yothandiza.
Nthawi yotumiza: Aug-01-2023